Project Summary

This database contains a collection of imaging and omic data reporting on triple negative breast cancer in both patients and patient derive xenografts (PDXs).

Figure 1 illustrates representative imaging data obtained for this project consisting of dynamic contrast enhanced MRI (DCE-MRI) and diffusion weighted MRI are acquired before and during the course of a therapeutic regimen (docetaxel and carboplatin). One parameter returned from DCE-MRI is Ktrans which is the volume transfer constant estimating tumor perfusion and vessel permeability; the left panel of each frame presents an example of a Ktrans map overlain on a corresponding anatomical image. A second parameter returned from DW-MRI is the ADC or apparent diffusion coefficient of water which is a marker of tissue cellularity; the right panel of each frame presents an example of an ADC map overlain on a corresponding anatomical image. The images are then analyzed in a number of quantitative image features as described on the Image Feature Summary tab. In addition, treatment response is computed according to RECIST criteria (human data) and tumor volume (animal data).













  


  Progressive Disease (PD)        Complete Response (CR)        Stable Disease (SD)        Partial Response (PR)



  
Patients
PDX